Endocrine Abstracts

IntroductionWe have previously demonstrated profound effects of hormone replacement treatment (HRT) in post-menopausal women on the IGF-system. HRT is widely used to prevent osteoporosis. The IGF-system has been implicated in bone formation. IGFBP-4 and IGFBP-5 are known to be important in modulation of IGF activity in bone. In this larger study we have examined the effects of HRT on circulating IGFBP-4 levels.MethodOral conjugated equine estrogen (CEE) alone or in...

Introduction: Propensity to centripetal adiposity is an ethnic characteristic amongst South Asians, which may underlie the excess risk for both coronary heart disease (CHD) and diabetes in this population. Circulating levels of adipocytokines (hormones which include leptin, adiponectin, tumour necrosis factor (TNF-alpha)) and C-reactive protein (CRP) reflect the adipose tissues endocrine and metabolic activity, and are implicated in CHD.Methods: We compa...

AimsThe increasing incidence of type 2 diabetes mellitus with age in the context of ageing populations worldwide highlights the need to understand better factors that influence glucose homeostasis. Our hypothesis was that lifestyle change accompanying migration influences the relationship between pancreatic beta cell function (HOMA-B) and age.MethodsWe compared a specific migrant Gujarati community in Britain...

IntroductionThe IGF-system has also been implicated in the pathogenesis of diabetes and cardiovascular disease. We report the effects of total energy intake on the IGF-system in two populations with a markedly different dietary macronutrient intake and cardiovascular event rate.MethodDietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell UK (n=205) compared with people ...

Introduction: Compared to ethnically European men, Pakistani origin men living in the UK have a lower circulating total and free testosterone level, corresponding with greater central adiposity and higher insulin resistance. Within a South Asian group we have now examined the effect of migration to the UK on male testosterone level.Methods: Circulating testosterone concentration was measured by automated immunoassay in 97 Gujarati males resident in India...

Background: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes.Aims: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with a...

Background: Obesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes.Aims: To evaluate changes in lipoproteins, insulin resistance, mediators of systemic and vascular inflammation and endothelial dysfunction following Roux-en-Y bariatric surgery in obese patients with a...